Everything can be hacked. There is no such thing as perfect security. It's only degrees of difficulty.

Ledger is about as hard as it could get though (assuming it's not backdoored by design).
I think they use a different form of security, I'm not an expert....I'm busy trading at the moment but I think it's called Security Enclave....similar to what iDevices used and/or using.

But IMHO, I'm certain the real wizards/engineers that created these devices also have ways to go around the same security implementations they had implemented/selling. (Not that the engineers will steal your coins, a teenage wiz/genius hacker might 😂)